Migfilin Protein Promotes Migration and Invasion in Human Glioma through Epidermal Growth Factor Receptor-mediated Phospholipase C-γ and STAT3 Protein Signaling Pathways*

نویسندگان

  • Yunwei Ou
  • Ling Ma
  • Lijia Dong
  • Liying Ma
  • Zitong Zhao
  • Li Ma
  • Wei Zhou
  • Jing Fan
  • Chuanyue Wu
  • Chunjiang Yu
  • Qimin Zhan
  • Yongmei Song
چکیده

Migfilin is critical for cell shape and motile regulation. However, its pathological role in glioma is unknown. Using an immunohistochemical staining assay, we demonstrate that there is a significant correlation between expression of Migfilin and pathological tumor grade in 217 clinical glioma samples. High Migfilin expression is associated with poor prognosis for patients with glioma. Investigation of the molecular mechanism shows that Migfilin promotes migration and invasion in glioma cells. Moreover, Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-γ and STAT3-signaling pathways. Our results may provide significant clinical application, including use of Migfilin as a molecular marker in glioma for early diagnosis and as an indicator of prognosis.

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عنوان ژورنال:

دوره 287  شماره 

صفحات  -

تاریخ انتشار 2012